The pyrazole ring, frequently present in bioactive compounds like drugs, has gained popularity for its combination with fluorine atoms. Their strong C−F bonds and polarity modify crucial physicochemical properties such as pKa values, metabolic stability, lipophilicity, potency, and selectivity, thereby fueling the increasing interest in fluorinated pyrazoles.*

At Abovchem, a division of BirdoTech, we've developed methodologies for synthesizing diverse 3-fluoropyrazole derivatives. For more information, feel free to reach out to us at sales@abovchem.com.

                                      

* Mykhailiuk, P. K.  Fluorinated Pyrazoles: From Synthesis to Applications, Chemical Reviews 2021, 121, 3, 1670-1715