Recently, there has been a growing interest in saturated (hetero)fused cyclopropanes, such as 3-azabicyclo[3.1.0]hexane, within drug discovery. These compounds not only position critical pharmacophores in precise three-dimensional configurations but also impart advantageous physicochemical properties, such as enhancing metabolic stability, modifying logP and pKa values, among others. At #Abovchem, we've developed synthetic methodologies to produce the following specific building blocks that integrate these motifs into your drug design, customized to align with your needs.